Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join a prestigious hospital's surgical unit. Unable to personally connect with those around him, Shaun uses his extraordinary medical gifts to save lives and challenge the skepticism of his colleagues.
Shaun and Lea’s long-awaited wedding reception is interrupted by a violent attack at the hospital and the entire team must mobilize to save the victims. Meanwhile, the trauma of seeing people he cares for in life-threatening situations is affecting Shaun in more ways than one.
On their first day as surgical attendings, Dr. Shaun Murphy and Dr. Alex Park are introduced to the first year residents they will be overseeing, Dr. Danica Powell and Dr. Daniel Perez,who make quite the first impression. Meanwhile, Lim returns to work while facing her new reality and the emotions surrounding the changes.
The team treats a famous marriage counselor after she injures her ankle from falling, but when she offers relationship advice to them, Dr. Morgan Reznick quickly spots that their patient might be experiencing something far more serious. Meanwhile, Dr. Audrey Lim is determined to get to the bottom of what really happened in the OR during her surgery and sets off on her own internal investigation.
The team operates on a military reenactor whose attempt at authenticity has created an explosive predicament that even Dr. Shaun Murphy couldn’t predict. Meanwhile, Dr. Jordan Allen and Dr. Daniel Perez are on a race against time as they search for a severed foot.
Shaun, Asher and Powell treat a young patient on Halloween with a rare hereditary disease, sending them down an uncharted path. Meanwhile, Glassman and Shaun must overcome their differences to work together to try and find a solution for Lim’s paralysis.
In the midst of a heatwave, Dr. Shaun Murphy and Dr. Danica Powell are at odds when it comes to their patient’s surgery. Their heated stalemate tests Shaun’s patience and his willingness to compromise. Meanwhile, when the hospital loses power, Lea and Dr. Aaron Glassman are forced to come up with a quick solution or risk a total shutdown that could risk patients’ lives on the 100th episode.
When a woman pregnant with sextuplets arrives at the hospital, Dr. Marcus Andrews must split the doctors into teams to ensure their health and safety following their high-risk delivery. Meanwhile, Shaun and Lea must face their own hurdles as they discuss starting a family.
Drs. Shaun Murphy, Asher Wolke and Aaron Glassman meet a patient with an infected surgical sponge that was left in their abdomen. Meanwhile, Dr. Morgan Park must face her own past when she treats the victim of a sexual assault.
Dr. Shaun Murphy unknowingly creates a competition between Drs. Danica Powell and Daniel Perez when he introduces a new performance rating system; Dr. Morgan Reznick may have crossed a line with Dr. Alex Park.
Shaun and Lea soon learn that their surprise pregnancy may also come with additional complications. Meanwhile, Doctors Park, Reznick and Allen treat a teen with Gardner’s syndrome whose past surgical history jeopardizes the outcome of his current one.
On the way to their babymoon, Lea and Shaun get a quick lesson in parenting when they rush to aid an injured dog. Meanwhile, Dr. Danica Powell secretly performs an operation on a friend that could jeopardize her career.
Shaun invites Aaron to stay with him while he has exterminators at his house and Lea realizes both men have a lot more in common than she realized. Meanwhile, Dr. Morgan Reznick wrestles with a big decision about her career and her personal life.